Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 1
Ligand
BDBM50452474
Substrate
n/a
Meas. Tech.
ChEMBL_1747591 (CHEMBL4182101)
EC50
900±n/a nM
Citation
 Iwaki, T; Tanaka, T; Miyazaki, K; Suzuki, Y; Okamura, Y; Yamaki, A; Iwanami, M; Morozumi, N; Furuya, M; Oyama, Y Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A. Bioorg Med Chem 25:6680-6694 (2017) [PubMed]  Article 
Target
Name:
Atrial natriuretic peptide receptor 1
Synonyms:
ANP-A | ANPRA | ANPRA_HUMAN | Atrial natriuretic peptide A-type receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor A | GC-A | Guanylate cyclase | NPR-A | NPR1
Type:
PROTEIN
Mol. Mass.:
118919.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_700223
Residue:
1061
Sequence:
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
  
Inhibitor
Name:
BDBM50452474
Synonyms:
CHEMBL4217523
Type:
Small organic molecule
Emp. Form.:
C28H35N5O3
Mol. Mass.:
489.6092
SMILES:
C[C@H](CO)Nc1nc(N[C@H]2CC[C@@H](CC2)NC(=O)[C@H]2C[C@H](O)C2)c2cc(ccc2n1)-c1ccccc1 |r,wU:9.8,1.0,20.21,wD:12.15,18.18,(44.29,-21.96,;44.3,-20.44,;45.62,-19.68,;46.95,-20.46,;42.98,-19.67,;41.65,-20.43,;41.64,-21.97,;40.3,-22.74,;40.29,-24.28,;41.62,-25.05,;42.96,-24.29,;44.29,-25.06,;44.28,-26.6,;42.94,-27.37,;41.62,-26.59,;45.61,-27.38,;46.94,-26.62,;46.95,-25.1,;48.26,-27.4,;48.64,-28.87,;50.12,-28.49,;51.44,-29.27,;49.73,-27.01,;38.97,-21.96,;37.64,-22.72,;36.3,-21.94,;36.31,-20.4,;37.65,-19.64,;38.98,-20.42,;40.32,-19.66,;34.96,-22.71,;34.96,-24.25,;33.62,-25.01,;32.29,-24.24,;32.3,-22.7,;33.63,-21.93,)|
Structure:
Search PDB for entries with ligand similarity: