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Target
7-methylguanosine phosphate-specific 5'-nucleotidase
Ligand
BDBM50452630
Substrate
n/a
Meas. Tech.
ChEMBL_1747997 (CHEMBL4182507)
IC50
87800±n/a nM
Citation
 Kozarski, M; Kubacka, D; Wojtczak, BA; Kasprzyk, R; Baranowski, MR; Kowalska, J 7-Methylguanosine monophosphate analogues with 5'-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase. Bioorg Med Chem 26:191-199 (2018) [PubMed]  Article 
Target
Name:
7-methylguanosine phosphate-specific 5'-nucleotidase
Synonyms:
3.1.3.5 | 3.1.3.91 | 5NT3B_HUMAN | 7-methylguanosine nucleotidase | NT5C3B | NT5C3L | cN-III-like protein
Type:
PROTEIN
Mol. Mass.:
34388.07
Organism:
Homo sapiens
Description:
ChEMBL_118166
Residue:
300
Sequence:
MAEEVSTLMKATVLMRQPGRVQEIVGALRKGGGDRLQVISDFDMTLSRFAYNGKRCPSSYNILDNSKIISEECRKELTALLHHYYPIEIDPHRTVKEKLPHMVEWWTKAHNLLCQQKIQKFQIAQVVRESNAMLREGYKTFFNTLYHNNIPLFIFSAGIGDILEEIIRQMKVFHPNIHIVSNYMDFNEDGFLQGFKGQLIHTYNKNSSACENSGYFQQLEGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVEERRERYMDSYDIVLEKDETLDVVNGLLQHILCQGVQLEMQGP
  
Inhibitor
Name:
BDBM50452630
Synonyms:
CHEMBL4203412
Type:
Small organic molecule
Emp. Form.:
C13H17N8O7P
Mol. Mass.:
428.2972
SMILES:
C[n+]1cn([C@@H]2O[C@H](Cn3cc(nn3)P(O)([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r|
Structure:
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