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Target
Metallo-beta-lactamase type 2
Ligand
BDBM50452815
Substrate
n/a
Meas. Tech.
ChEMBL_1748419 (CHEMBL4182929)
Ki
5110±n/a nM
Citation
 Zhang, E; Wang, MM; Huang, SC; Xu, SM; Cui, DY; Bo, YL; Bai, PY; Hua, YG; Xiao, CL; Qin, S NOTA analogue: A first dithiocarbamate inhibitor of metallo-?-lactamases. Bioorg Med Chem Lett 28:214-221 (2018) [PubMed]  Article 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
B2 metallo-beta-lactamase | BLAN1_KLEPN | Beta-lactamase NDM-1 | Beta-lactamase type II | Metallo-beta-lactamase NDM-1 | Metallo-beta-lactamase type 2 | Metallo-beta-lactamase type II | NDM-1 | New Delhi metallo-beta-lactamase-1 | blaNDM-1
Type:
PROTEIN
Mol. Mass.:
28498.15
Organism:
Klebsiella pneumoniae
Description:
ChEMBL_103887
Residue:
270
Sequence:
MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
  
Inhibitor
Name:
BDBM50452815
Synonyms:
CHEMBL2005280
Type:
Small organic molecule
Emp. Form.:
C12H21N3O6
Mol. Mass.:
303.3116
SMILES:
OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1
Structure:
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