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Target
Calcium/calmodulin-dependent protein kinase type II subunit delta/gamma
Ligand
BDBM292489
Substrate
n/a
Meas. Tech.
ChEMBL_1749666 (CHEMBL4184426)
EC50
6.2±n/a nM
Citation
  TBA Bioorg Med Chem Lett 28:541-546 (2018) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit delta/gamma
Synonyms:
CaM kinase II delta/gamma
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1749666
Components:
This complex has 2 components.
Component 1
Name:
Calcium/calmodulin-dependent protein kinase type II subunit delta
Synonyms:
2.7.11.17 | CaM kinase II subunit delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta | Camk2d | KCC2D_RAT
Type:
PROTEIN
Mol. Mass.:
60087.51
Organism:
Rattus norvegicus
Description:
ChEMBL_118321
Residue:
533
Sequence:
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKANVVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
  
Component 2
Name:
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Synonyms:
2.7.11.17 | CaM kinase II subunit gamma | CaMK-II subunit gamma | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Camk2g | KCC2G_RAT
Type:
PROTEIN
Mol. Mass.:
59049.59
Organism:
Rattus norvegicus
Description:
ChEMBL_118321
Residue:
527
Sequence:
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
  
Inhibitor
Name:
BDBM292489
Synonyms:
(S)-N-(2-(diethylamino)propyl)-2-(3-hydroxyazetidin-1-yl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide | US10100058, Example 145
Type:
Small organic molecule
Emp. Form.:
C26H31N7O2S
Mol. Mass.:
505.635
SMILES:
CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(O)C1 |r|
Structure:
Search PDB for entries with ligand similarity: