Reaction Details Report a problem with these data
Target
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Ligand
BDBM292485
Substrate
n/a
Meas. Tech.
ChEMBL_1749666 (CHEMBL4184426)
EC50
7.4±n/a nM
Citation
  TBA Bioorg Med Chem Lett 28:541-546 (2018) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Synonyms:
2.7.11.17 | CaM kinase II subunit gamma | CaMK-II subunit gamma | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Camk2g | KCC2G_RAT
Type:
PROTEIN
Mol. Mass.:
59049.59
Organism:
Rattus norvegicus
Description:
ChEMBL_118321
Residue:
527
Sequence:
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
  
Inhibitor
Name:
BDBM292485
Synonyms:
(S)-N-(2-(diethylamino)propyl)-2-(3-methoxyazetidin-1-yl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide | US10100058, Example 141
Type:
Small organic molecule
Emp. Form.:
C27H33N7O2S
Mol. Mass.:
519.662
SMILES:
CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C1)OC |r|
Structure:
Search PDB for entries with ligand similarity: