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Target
DNA-(apurinic or apyrimidinic site) endonuclease
Ligand
BDBM42119
Substrate
n/a
Meas. Tech.
ChEMBL_1750387 (CHEMBL4185147)
IC50
1700±n/a nM
Citation
 Laev, SS; Salakhutdinov, NF; Lavrik, OI Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1). Bioorg Med Chem 25:2531-2544 (2017) [PubMed]  Article 
Target
Name:
DNA-(apurinic or apyrimidinic site) endonuclease
Synonyms:
APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1
Type:
Protein
Mol. Mass.:
35560.12
Organism:
Homo sapiens (Human)
Description:
P27695
Residue:
318
Sequence:
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL
  
Inhibitor
Name:
BDBM42119
Synonyms:
2-[4-(2,5-dimethyl-1-pyrrolyl)phenoxy]acetic acid | 2-[4-(2,5-dimethylpyrrol-1-yl)phenoxy]acetic acid | 2-[4-(2,5-dimethylpyrrol-1-yl)phenoxy]ethanoic acid | BIM-0001419.P001 | cid_776871
Type:
Small organic molecule
Emp. Form.:
C14H15NO3
Mol. Mass.:
245.2738
SMILES:
Cc1ccc(C)n1-c1ccc(OCC(O)=O)cc1
Structure:
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