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Target
E3 ubiquitin-protein ligase RNF31/RanBP-type and C3HC4-type zinc finger-containing protein 1/Sharpin
Ligand
BDBM50134315
Substrate
n/a
Meas. Tech.
ChEMBL_1750753 (CHEMBL4185513)
IC50
510±n/a nM
Citation
 Buuh, ZY; Lyu, Z; Wang, RE Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins. J Med Chem 61:3239-3252 (2018) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase RNF31/RanBP-type and C3HC4-type zinc finger-containing protein 1/Sharpin
Synonyms:
Sharpin/RBCK1/RNF31
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1750753
Components:
This complex has 3 components.
Component 1
Name:
Sharpin
Synonyms:
SHARPIN | SHRPN_HUMAN | SIPL1 | Shank-associated RH domain-interacting protein | Shank-interacting protein-like 1 | hSIPL1
Type:
PROTEIN
Mol. Mass.:
39944.77
Organism:
Homo sapiens
Description:
ChEMBL_118340
Residue:
387
Sequence:
MAPPAGGAAAAASDLGSAAVLLAVHAAVRPLGAGPDAEAQLRRLQLSADPERPGRFRLELLGAGPGAVNLEWPLESVSYTIRGPTQHELQPPPGGPGTLSLHFLNPQEAQRWAVLVRGATVEGQNGSKSNSPPALGPEACPVSLPSPPEASTLKGPPPEADLPRSPGNLTEREELAGSLARAIAGGDEKGAAQVAAVLAQHRVALSVQLQEACFPPGPIRLQVTLEDAASAASAASSAHVALQVHPHCTVAALQEQVFSELGFPPAVQRWVIGRCLCVPERSLASYGVRQDGDPAFLYLLSAPREAPATGPSPQHPQKMDGELGRLFPPSLGLPPGPQPAASSLPSPLQPSWSCPSCTFINAPDRPGCEMCSTQRPCTWDPLAAAST
  
Component 2
Name:
RanBP-type and C3HC4-type zinc finger-containing protein 1
Synonyms:
2.3.2.31 | C20orf18 | HBV-associated factor 4 | HOIL-1 | HOIL1_HUMAN | Heme-oxidized IRP2 ubiquitin ligase 1 | Hepatitis B virus X-associated protein 4 | RBCK1 | RING finger protein 54 | RING-type E3 ubiquitin transferase HOIL-1 | RNF54 | RanBP-type and C3HC4-type zinc finger-containing protein 1 | UBCE7IP3 | Ubiquitin-conjugating enzyme 7-interacting protein 3 | XAP3 | XAP4
Type:
PROTEIN
Mol. Mass.:
57563.56
Organism:
Homo sapiens
Description:
ChEMBL_118340
Residue:
510
Sequence:
MDEKTKKAEEMALSLTRAVAGGDEQVAMKCAIWLAEQRVPLSVQLKPEVSPTQDIRLWVSVEDAQMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPVLQQWVIGQRLARDQETLHSHGVRQNGDSAYLYLLSARNTSLNPQELQRERQLRMLEDLGFKDLTLQPRGPLEPGPPKPGVPQEPGRGQPDAVPEPPPVGWQCPGCTFINKPTRPGCEMCCRARPEAYQVPASYQPDEEERARLAGEEEALRQYQQRKQQQQEGNYLQHVQLDQRSLVLNTEPAECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVSCPFIDNTYSCSGKLLEREIKALLTPEDYQRFLDLGISIAENRSAFSYHCKTPDCKGWCFFEDDVNEFTCPVCFHVNCLLCKAIHEQMNCKEYQEDLALRAQNDVAARQTTEMLKVMLQQGEAMRCPQCQIVVQKKDGCDWIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQNCH
  
Component 3
Name:
E3 ubiquitin-protein ligase RNF31
Synonyms:
2.3.2.31 | E3 ubiquitin-protein ligase RNF31 | HOIL-1-interacting protein | HOIP | RING finger protein 31 | RING-type E3 ubiquitin transferase RNF31 | RNF31 | RNF31_HUMAN | ZIBRA | Zinc in-between-RING-finger ubiquitin-associated domain protein
Type:
PROTEIN
Mol. Mass.:
119651.81
Organism:
Homo sapiens
Description:
ChEMBL_118340
Residue:
1072
Sequence:
MPGEEEERAFLVAREELASALRRDSGQAFSLEQLRPLLASSLPLAARYLQLDAARLVRCNAHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRGVKFNNPVFRSTVDAVQGGRDVLRLYGYTEEQPDGLSFPEGQEEPDEHQVATVTLEVLLLRTELSLLLQNTHPRQQALEQLLEDKVEDDMLQLSEFDPLLREIAPGPLTTPSVPGSTPGPCFLCGSAPGTLHCPSCKQALCPACDHLFHGHPSRAHHLRQTLPGVLQGTHLSPSLPASAQPRPQSTSLLALGDSSLSSPNPASAHLPWHCAACAMLNEPWAVLCVACDRPRGCKGLGLGTEGPQGTGGLEPDLARGRWACQSCTFENEAAAVLCSICERPRLAQPPSLVVDSRDAGICLQPLQQGDALLASAQSQVWYCIHCTFCNSSPGWVCVMCNRTSSPIPAQHAPRPYASSLEKGPPKPGPPRRLSAPLPSSCGDPEKQRQDKMREEGLQLVSMIREGEAAGACPEEIFSALQYSGTEVPLQWLRSELPYVLEMVAELAGQQDPGLGAFSCQEARRAWLDRHGNLDEAVEECVRTRRRKVQELQSLGFGPEEGSLQALFQHGGDVSRALTELQRQRLEPFRQRLWDSGPEPTPSWDGPDKQSLVRRLLAVYALPSWGRAELALSLLQETPRNYELGDVVEAVRHSQDRAFLRRLLAQECAVCGWALPHNRMQALTSCECTICPDCFRQHFTIALKEKHITDMVCPACGRPDLTDDTQLLSYFSTLDIQLRESLEPDAYALFHKKLTEGVLMRDPKFLWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRSCEDFQNWKRMNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPEPNCRVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEPPAGARAVPGGGCRVIEQKEVPNGLRDEACGKETPAGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATERYLHVRPQPLAGEDPPAYQARLLQKLTEEVPLGQSIPRRRK
  
Inhibitor
Name:
BDBM50134315
Synonyms:
7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-9,12-diazatetracyclo[9.2.2.01,9.03,8]pentadeca-3,5-diene-10,13-dione | CHEMBL331627 | GLIOTOXIN
Type:
Small organic molecule
Emp. Form.:
C13H14N2O4S2
Mol. Mass.:
326.391
SMILES:
CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3 |r,c:8,t:6,THB:12:13:1.2:19.20,15:14:1.2:19.20|
Structure:
Search PDB for entries with ligand similarity: