Reaction Details Report a problem with these data
Target
Phosphate regulon sensor protein PhoR
Ligand
BDBM50453879
Substrate
n/a
Meas. Tech.
ChEMBL_1751467 (CHEMBL4186227)
IC50
16000±n/a nM
Citation
 Vo, CD; Shebert, HL; Zikovich, S; Dryer, RA; Huang, TP; Moran, LJ; Cho, J; Wassarman, DR; Falahee, BE; Young, PD; Gu, GH; Heinl, JF; Hammond, JW; Jackvony, TN; Frederick, TE; Blair, JA Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. Bioorg Med Chem Lett 27:5235-5244 (2017) [PubMed]  Article 
Target
Name:
Phosphate regulon sensor protein PhoR
Synonyms:
2.7.13.3 | PHOR_ECOLI | Phosphate regulon sensor protein PhoR | nmpB | nmpB | phoR
Type:
PROTEIN
Mol. Mass.:
49647.45
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_117812
Residue:
431
Sequence:
MLERLSWKRLVLELLLCCLPAFILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLLYGLHQMQLRNKKRRRELGNLIKRFRSGAESLPDAVVLTTEEGGIFWCNGLAQQILGLRWPEDNGQNILNLLRYPEFTQYLKTRDFSRPLNLVLNTGRHLEIRVMPYTHKQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMNEQPLEGAVREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTHLLNEKVDVPMMLRVVEREAQTLSQKKQTFTFEIDNGLKVSGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPHGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHAVNHHESRLNIESTVGKGTRFSFVIPERLIAKNSD
  
Inhibitor
Name:
BDBM50453879
Synonyms:
CHEMBL4202687
Type:
Small organic molecule
Emp. Form.:
C18H21FO
Mol. Mass.:
272.3571
SMILES:
CCC(C(CC)c1ccc(F)cc1)c1ccc(O)cc1
Structure:
Search PDB for entries with ligand similarity: