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Target
Histidine kinase
Ligand
BDBM50453885
Substrate
n/a
Meas. Tech.
ChEMBL_1751463 (CHEMBL4186223)
IC50
75000±n/a nM
Citation
 Vo, CD; Shebert, HL; Zikovich, S; Dryer, RA; Huang, TP; Moran, LJ; Cho, J; Wassarman, DR; Falahee, BE; Young, PD; Gu, GH; Heinl, JF; Hammond, JW; Jackvony, TN; Frederick, TE; Blair, JA Repurposing Hsp90 inhibitors as antibiotics targeting histidine kinases. Bioorg Med Chem Lett 27:5235-5244 (2017) [PubMed]  Article 
Target
Name:
Histidine kinase
Synonyms:
Sensor protein kinase WalK family protein
Type:
PROTEIN
Mol. Mass.:
51701.71
Organism:
Streptococcus pneumoniae PCS8203
Description:
ChEMBL_117803
Residue:
449
Sequence:
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSEVIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPELLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALCETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIWMEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLGLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED
  
Inhibitor
Name:
BDBM50453885
Synonyms:
CHEMBL4209595
Type:
Small organic molecule
Emp. Form.:
C14H10N4OS2
Mol. Mass.:
314.385
SMILES:
Nc1nc2ccc(Oc3ccc4nc(N)sc4c3)cc2s1
Structure:
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