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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM46004
Substrate
n/a
Meas. Tech.
ChEMBL_1751742 (CHEMBL4186502)
IC50
4510±n/a nM
Citation
 Pinkerton, AB; Sergienko, E; Bravo, Y; Dahl, R; Ma, CT; Sun, Q; Jackson, MR; Cosford, NDP; Millán, JL Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg Med Chem Lett 28:31-34 (2018) [PubMed]  Article 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM46004
Synonyms:
5-chloranyl-2-methoxy-N-quinolin-3-yl-benzenesulfonamide | 5-chloro-2-methoxy-N-(3-quinolinyl)benzenesulfonamide | 5-chloro-2-methoxy-N-(3-quinolyl)benzenesulfonamide | 5-chloro-2-methoxy-N-quinolin-3-ylbenzenesulfonamide | MLS-0202007.0001 | US10370333, Example II-1 | cid_4679684
Type:
Small organic molecule
Emp. Form.:
C16H13ClN2O3S
Mol. Mass.:
348.804
SMILES:
COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2ccccc2c1
Structure:
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