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Target
Casein kinase I isoform delta
Ligand
BDBM50454244
Substrate
n/a
Meas. Tech.
ChEMBL_1752434 (CHEMBL4187194)
IC50
215±n/a nM
Citation
 Monastyrskyi, A; Nilchan, N; Quereda, V; Noguchi, Y; Ruiz, C; Grant, W; Cameron, M; Duckett, D; Roush, W Development of dual casein kinase 1?/1? (CK1?/?) inhibitors for treatment of breast cancer. Bioorg Med Chem 26:590-602 (2018) [PubMed]  Article 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta)
Type:
Enzyme
Mol. Mass.:
47356.76
Organism:
Homo sapiens (Human)
Description:
P48730
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM50454244
Synonyms:
CHEMBL4210412
Type:
Small organic molecule
Emp. Form.:
C25H23FN8O
Mol. Mass.:
470.5015
SMILES:
Fc1cccc(c1)-n1cnc2c(NCc3nc(c[nH]3)-c3ccccc3)nc(nc12)N1CCOCC1
Structure:
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