Reaction Details Report a problem with these data
Target
Regulator of G-protein signaling 17
Ligand
BDBM25525
Substrate
n/a
Meas. Tech.
ChEMBL_1756640 (CHEMBL4191648)
Kd
1000±n/a nM
Citation
 Bodle, CR; Mackie, DI; Hayes, MP; Schamp, JH; Miller, MR; Henry, MD; Doorn, JA; Houtman, JCD; James, MA; Roman, DL Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines. J Nat Prod 80:1992-2000 (2017) [PubMed]  Article 
Target
Name:
Regulator of G-protein signaling 17
Synonyms:
RGS17 | RGS17_HUMAN | RGSZ2
Type:
PROTEIN
Mol. Mass.:
24356.71
Organism:
Homo sapiens
Description:
ChEMBL_118219
Residue:
210
Sequence:
MRKRQQSQNEGTPAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVRNEERGENAGRPTHTTKMESIQVLEECQNPTAEEVLSWSQNFDKMMKAPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKVIEEKARMIYEDYISILSPKEVSLDSRVREVINRNLLDPNPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKSFVESTAGSSSES
  
Inhibitor
Name:
BDBM25525
Synonyms:
24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0^{2,10}.0^{4,8}.0^{14,22}.0^{17,21}]tetracosa-1(13),2,4(8),9,11,14(22),15,17(21),23-nonaen-24-ium | CHEMBL490129 | Pseudochelerythrine | Veadent | cid_5154 | sanguinarine | sangvinarin
Type:
Small organic molecule
Emp. Form.:
C20H14NO4
Mol. Mass.:
332.3289
SMILES:
C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
Structure:
Search PDB for entries with ligand similarity: