Reaction Details Report a problem with these data
Target
Glutamate receptor 2
Ligand
BDBM50456718
Substrate
n/a
Meas. Tech.
ChEMBL_1757902 (CHEMBL4192910)
Ki
1740±n/a nM
Citation
 Szyma?ska, E; Nielsen, B; Johansen, TN; Cuņado Moral, AM; Pickering, DS; Szczepa?ska, K; Mickowska, A; Kie?-Kononowicz, K Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors. Eur J Med Chem 138:874-883 (2017) [PubMed]  Article 
Target
Name:
Glutamate receptor 2
Synonyms:
GRIA2_RAT | Glur2 | Glutamate receptor AMPA 2/4 | Glutamate receptor ionotropic, AMPA 2 | Gria2
Type:
PROTEIN
Mol. Mass.:
98691.74
Organism:
Rattus norvegicus
Description:
ChEMBL_936441
Residue:
883
Sequence:
MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI
  
Inhibitor
Name:
BDBM50456718
Synonyms:
CHEMBL4208162
Type:
Small organic molecule
Emp. Form.:
C15H13ClN2O6
Mol. Mass.:
352.727
SMILES:
N[C@H](Cc1cc(c(Cl)c(c1)[N+]([O-])=O)-c1cc(O)ccc1O)C(O)=O |r|
Structure:
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