Reaction Details
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Adenosine receptor A2a
Ligand
BDBM50457103
Substrate
n/a
Meas. Tech.
ChEMBL_1758725 (CHEMBL4193733)
Ki
1.1±n/a nM
Citation
Basu, S; Barawkar, DA; Ramdas, V; Naykodi, M; Shejul, YD; Patel, M; Thorat, S; Panmand, A; Kashinath, K; Bonagiri, R; Prasad, V; Bhat, G; Quraishi, A; Chaudhary, S; Magdum, A; Meru, AV; Ghosh, I; Bhamidipati, RK; Raje, AA; Madgula, VLM; De, S; Rouduri, SR; Palle, VP; Chugh, A; Hariharan, N; Mookhtiar, KA Discovery of Potent and Selective A ACS Med Chem Lett 8:835-840 (2017) [PubMed] Article More Info.:
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45015.65
Organism:
Rattus norvegicus (rat)
Description:
Rat A2A receptors expressed in CHO cells.
Residue:
410
Sequence:
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
Inhibitor
Name:
BDBM50457103
Synonyms:
CHEMBL4217668
Type:
Small organic molecule
Emp. Form.:
C24H25F2N9O3
Mol. Mass.:
525.5106
SMILES:
Cn1c2c(nc(N)n3nc(nc23)-c2ccco2)n(CCN2CCN(CC2)c2ccc(OC(F)F)cc2)c1=O
Structure:
