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Target
Lysine--tRNA ligase
Ligand
BDBM50457624
Substrate
n/a
Meas. Tech.
ChEMBL_1760358 (CHEMBL4195366)
IC50
5800±n/a nM
Citation
 Das, P; Babbar, P; Malhotra, N; Sharma, M; Jachak, GR; Gonnade, RG; Shanmugam, D; Harlos, K; Yogavel, M; Sharma, A; Reddy, DS Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite. J Med Chem 61:5664-5678 (2018) [PubMed]  Article 
Target
Name:
Lysine--tRNA ligase
Synonyms:
6.1.1.6 | Lysine--tRNA ligase | Lysyl-tRNA synthetase
Type:
PROTEIN
Mol. Mass.:
67597.87
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_108434
Residue:
583
Sequence:
MTSKSFLLSFLKYKHVNTYIFEKSFSKILKNTKKHIDCHLKSCFVTMNEKKEHVLEGEKNKRVVNASKDKKKEEEGEVDPRLYFENRSKFIQDQKDKGINPYPHKFERTISIPEFIEKYKDLGNGEHLEDTILNITGRIMRVSASGQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAECYDKIRRGDIVGIVGFPGKSKKGELSIFPKETILLSACLHMLPMKYGLKDTEIRYRQRYLDLLINESSRHTFVTRTKIINFLRNFLNERGFFEVETPMMNLIAGGANARPFITHHNDLDLDLYLRIATELPLKMLIVGGIDKVYEIGKVFRNEGIDNTHNPEFTSCEFYWAYADYNDLIKWSEDFFSQLVYHLFGTYKISYNKDGPENQPIEIDFTPPYPKVSIVEEIEKVTNTILEQPFDSNETIEKMINIIKEHKIELPNPPTAAKLLDQLASHFIENKYNDKPFFIVEHPQIMSPLAKYHRTKPGLTERLEMFICGKEVLNAYTELNDPFKQKECFKLQQKDREKGDTEAAQLDSAFCTSLEYGLPPTGGLGLGIDRITMFLTNKNSIKDVILFPTMRPAN
  
Inhibitor
Name:
BDBM50457624
Synonyms:
CHEMBL4215932
Type:
Small organic molecule
Emp. Form.:
C16H20O5
Mol. Mass.:
292.327
SMILES:
[H][C@@]1(C[C@H]2Cc3cc(O)cc(O)c3C(=O)O2)CCC[C@H](C)O1 |r|
Structure:
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