Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50457791
Substrate
n/a
Meas. Tech.
ChEMBL_1760683 (CHEMBL4195691)
IC50
1670±n/a nM
Citation
 Wang, CR; Wang, ZF; Shi, L; Wang, ZC; Zhu, HL Design, synthesis, and biological evaluation of pyrazole derivatives containing acetamide bond as potential BRAF Bioorg Med Chem Lett 28:2382-2390 (2018) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-raf | BRAF_MOUSE | Braf | Proto-oncogene B-Raf | Serine/threonine-protein kinase B-raf
Type:
PROTEIN
Mol. Mass.:
88789.83
Organism:
Mus musculus
Description:
ChEMBL_105657
Residue:
804
Sequence:
MAALSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLVFQTPTDASRNNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVPQEEASFPETALPSGSSSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDEKFPEVELQDQRDLIRDQGFRGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSSSEDRSRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
  
Inhibitor
Name:
BDBM50457791
Synonyms:
CHEMBL4215872
Type:
Small organic molecule
Emp. Form.:
C15H14ClN5O
Mol. Mass.:
315.758
SMILES:
Cn1cc(NC(=O)Cn2ccc(n2)-c2cccc(Cl)c2)cn1
Structure:
Search PDB for entries with ligand similarity: