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Target
Undecaprenyl-diphosphatase
Ligand
BDBM50458053
Substrate
n/a
Meas. Tech.
ChEMBL_1761928 (CHEMBL4197175)
IC50
8100±n/a nM
Citation
 Elsebaei, MM; Mohammad, H; Abouf, M; Abutaleb, NS; Hegazy, YA; Ghiaty, A; Chen, L; Zhang, J; Malwal, SR; Oldfield, E; Seleem, MN; Mayhoub, AS Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA). Eur J Med Chem 148:195-209 (2018) [PubMed]  Article 
Target
Name:
Undecaprenyl-diphosphatase
Synonyms:
3.6.1.27 | Bacitracin resistance protein | UPPP_ECOLI | Undecaprenyl pyrophosphate phosphatase | bacA | upk | uppP
Type:
PROTEIN
Mol. Mass.:
29763.97
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_117826
Residue:
273
Sequence:
MSDMHSLLIAAILGVVEGLTEFLPVSSTGHMIIVGHLLGFEGDTAKTFEVVIQLGSILAVVVMFWRRLFGLIGIHFGRPLQHEGESKGRLTLIHILLGMIPAVVLGLLFHDTIKSLFNPINVMYALVVGGLLLIAAECLKPKEPRAPGLDDMTYRQAFMIGCFQCLALWPGFSRSGATISGGMLMGVSRYAASEFSFLLAVPMMMGATALDLYKSWGFLTSGDIPMFAVGFITAFVVALIAIKTFLQLIKRISFIPFAIYRFIVAAAVYVVFF
  
Inhibitor
Name:
BDBM50458053
Synonyms:
CHEMBL4214440
Type:
Small organic molecule
Emp. Form.:
C18H19N5S
Mol. Mass.:
337.442
SMILES:
C\C(=N/NC(N)=N)c1sc(nc1C)-c1ccc(cc1)C#CC1CC1
Structure:
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