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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50022133
Substrate
n/a
Meas. Tech.
ChEBML_31928
IC50
75000±n/a nM
Citation
 DeRuiter, J; Brubaker, AN; Millen, J; Riley, TN Design and synthesis of 2-(arylamino)-4(3H)-quinazolinones as novel inhibitors of rat lens aldose reductase. J Med Chem 29:627-9 (1986) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50022133
Synonyms:
2-(4-Hydroxy-phenylamino)-3H-quinazolin-4-one: 0.17DMF | CHEMBL158893
Type:
Small organic molecule
Emp. Form.:
C14H11N3O2
Mol. Mass.:
253.256
SMILES:
Oc1ccc(Nc2nc3ccccc3c(=O)[nH]2)cc1
Structure:
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