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Target
Protein delta homolog 1
Ligand
BDBM50458548
Substrate
n/a
Meas. Tech.
ChEMBL_1764071 (CHEMBL4199318)
IC50
119±n/a nM
Citation
 Siu, M; Sengupta Ghosh, A; Lewcock, JW Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration. J Med Chem 61:8078-8087 (2018) [PubMed]  Article 
Target
Name:
Protein delta homolog 1
Synonyms:
DLK | DLK-1 | DLK1 | DLK1_HUMAN | FA1 | Fetal antigen 1 | pG2
Type:
PROTEIN
Mol. Mass.:
41294.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1444684
Residue:
383
Sequence:
MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI
  
Inhibitor
Name:
BDBM50458548
Synonyms:
CHEMBL4218417
Type:
Small organic molecule
Emp. Form.:
C26H25N3O3
Mol. Mass.:
427.495
SMILES:
CC(C)OCc1ccc2n(CCO)c3c4[nH]c5ccccc5c4c4CNC(=O)c4c3c2c1
Structure:
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