Reaction Details Report a problem with these data
Target
Prostaglandin D2 receptor 2
Ligand
BDBM50458655
Substrate
n/a
Meas. Tech.
ChEMBL_1764515 (CHEMBL4199762)
EC50
12±n/a nM
Citation
 Huang, X; Brubaker, J; Zhou, W; Biju, PJ; Xiao, L; Shao, N; Huang, Y; Dong, L; Liu, Z; Bitar, R; Buevich, A; Jung, J; Peterson, SL; Butcher, JW; Close, J; Martinez, M; MacCoss, RN; Zhang, H; Crawford, S; McCormick, KD; Aslanian, R; Nargund, R; Correll, C; Gervais, F; Qiu, H; Yang, X; Garlisi, C; Rindgen, D; Maloney, KM; Siliphaivanh, P; Palani, A Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma. ACS Med Chem Lett 9:679-684 (2018) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM50458655
Synonyms:
CHEMBL4207377
Type:
Small organic molecule
Emp. Form.:
C26H27N3O4S
Mol. Mass.:
477.575
SMILES:
[H][C@@]12CCC[C@]1([H])N(C(=O)OCc1ccccc1)c1ccccc1[C@@H]2N(CC)c1nc(cs1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: