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Target
Gap junction beta-2 protein
Ligand
BDBM50031282
Substrate
n/a
Meas. Tech.
ChEMBL_1764537 (CHEMBL4199784)
IC50
9400±n/a nM
Citation
 AlFindee, MN; Subedi, YP; Fiori, MC; Krishnan, S; Kjellgren, A; Altenberg, GA; Chang, CT Inhibition of Connexin Hemichannels by New Amphiphilic Aminoglycosides without Antibiotic Activity. ACS Med Chem Lett 9:697-701 (2018) [PubMed]  Article 
Target
Name:
Gap junction beta-2 protein
Synonyms:
CXB2_HUMAN | Connexin-26 | Cx26 | GJB2 | Gap junction beta-2 protein
Type:
PROTEIN
Mol. Mass.:
26226.37
Organism:
Homo sapiens
Description:
ChEMBL_117983
Residue:
226
Sequence:
MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV
  
Inhibitor
Name:
BDBM50031282
Synonyms:
CHEBI:17630 | Kanamycin
Type:
Small organic molecule
Emp. Form.:
C18H36N4O11
Mol. Mass.:
484.4986
SMILES:
NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O |r|
Structure:
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