Reaction Details Report a problem with these data
Target
Uracil nucleotide/cysteinyl leukotriene receptor
Ligand
BDBM50458838
Substrate
n/a
Meas. Tech.
ChEMBL_1764848 (CHEMBL4200095)
EC50
2300±n/a nM
Citation
 Baqi, Y; Pillaiyar, T; Abdelrahman, A; Kaufmann, O; Alshaibani, S; Rafehi, M; Ghasimi, S; Akkari, R; Ritter, K; Simon, K; Spinrath, A; Kostenis, E; Zhao, Q; Köse, M; Namasivayam, V; Müller, CE 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17. J Med Chem 61:8136-8154 (2018) [PubMed]  Article 
Target
Name:
Uracil nucleotide/cysteinyl leukotriene receptor
Synonyms:
G-protein coupled receptor 17 | GPR17_RAT | Gpr17 | UDP/CysLT receptor | Uracil nucleotide/cysteinyl leukotriene receptor
Type:
PROTEIN
Mol. Mass.:
37885.39
Organism:
Rattus norvegicus
Description:
ChEMBL_118052
Residue:
339
Sequence:
MDGLETALPSLTDNASLAYSEQCGQETPLENMLFACFYLLDFILAFVGNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIPCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWIVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALASLAVAFTFPFITTVTCYLLIIRSLRQGPRIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCSAQRALALGNRITSCLTSLNGALDPVMYFFVAEKFRHALCNLLCSKRLTGPPPSFEGKTNESSLSARSEL
  
Inhibitor
Name:
BDBM50458838
Synonyms:
CHEMBL4215280
Type:
Small organic molecule
Emp. Form.:
C18H22ClNO5
Mol. Mass.:
367.824
SMILES:
CCCCCCOc1cc(Cl)c2c(CCC(O)=O)c([nH]c2c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: