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Target
Uracil nucleotide/cysteinyl leukotriene receptor
Ligand
BDBM50004952
Substrate
n/a
Meas. Tech.
ChEMBL_1764849 (CHEMBL4200096)
EC50
1110±n/a nM
Citation
 Baqi, Y; Pillaiyar, T; Abdelrahman, A; Kaufmann, O; Alshaibani, S; Rafehi, M; Ghasimi, S; Akkari, R; Ritter, K; Simon, K; Spinrath, A; Kostenis, E; Zhao, Q; Köse, M; Namasivayam, V; Müller, CE 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17. J Med Chem 61:8136-8154 (2018) [PubMed]  Article 
Target
Name:
Uracil nucleotide/cysteinyl leukotriene receptor
Synonyms:
G-protein coupled receptor 17 | GPR17_MOUSE | Gpr17 | UDP/CysLT receptor | Uracil nucleotide/cysteinyl leukotriene receptor
Type:
PROTEIN
Mol. Mass.:
37855.38
Organism:
Mus musculus
Description:
ChEMBL_118109
Residue:
339
Sequence:
MNGLEAALPSLTDNSSLAYSEQCGQETPLENMLFACFYLLDFILAFVGNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIPCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWIVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALASLAVAFTFPFITTVTCYLLIIRSLRQGPRIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCAAQRALALGNRITSCLTSLNGALDPVMYFFVAEKFRHALCNLLCSKRLTGPPPSFEGKTNESSLSARSEL
  
Inhibitor
Name:
BDBM50004952
Synonyms:
3-(2-Carboxy-ethyl)-4,6-dichloro-1H-indole-2-carboxylic acid | CHEMBL31344
Type:
Small organic molecule
Emp. Form.:
C12H9Cl2NO4
Mol. Mass.:
302.11
SMILES:
OC(=O)CCc1c([nH]c2cc(Cl)cc(Cl)c12)C(O)=O
Structure:
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