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Target
Renin
Ligand
BDBM50022526
Substrate
n/a
Meas. Tech.
ChEBML_192896
IC50
>100000±n/a nM
Citation
 Iizuka, K; Kamijo, T; Kubota, T; Akahane, K; Umeyama, H; Kiso, Y New human renin inhibitors containing an unnatural amino acid, norstatine. J Med Chem 31:701-4 (1988) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50022526
Synonyms:
(-)2-Hydroxy-3-{3-(1H-imidazol-4-yl)-2-[3-naphthalen-1-yl-2-(phenethylcarbamoyl-methyl)-propionylamino]-propionylamino}-5-methyl-hexanoic acid methyl ester | 2-Hydroxy-3-{3-(1H-imidazol-4-yl)-2-[3-naphthalen-1-yl-2-(phenethylcarbamoyl-methyl)-propionylamino]-propionylamino}-5-methyl-hexanoic acid methyl ester | CHEMBL159462
Type:
Small organic molecule
Emp. Form.:
C37H45N5O6
Mol. Mass.:
655.7831
SMILES:
COC(=O)C(O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(=O)NCCc1ccccc1)Cc1cccc2ccccc12
Structure:
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