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Target
Insulin-degrading enzyme
Ligand
BDBM50459187
Substrate
n/a
Meas. Tech.
ChEMBL_1765700 (CHEMBL4200947)
IC50
44±n/a nM
Citation
 Yang, D; Qin, W; Shi, X; Zhu, B; Xie, M; Zhao, H; Teng, B; Wu, Y; Zhao, R; Yin, F; Ren, P; Liu, L; Li, Z Stabilized ?-Hairpin Peptide Inhibits Insulin Degrading Enzyme. J Med Chem 61:8174-8185 (2018) [PubMed]  Article 
Target
Name:
Insulin-degrading enzyme
Synonyms:
3.4.24.56 | IDE_MOUSE | Ide | Insulin degrading enzyme (mIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | Mouse Insulin Degrading Enzyme (mIDE)
Type:
n/a
Mol. Mass.:
117770.69
Organism:
Mus musculus (Mouse)
Description:
Q9JHR7
Residue:
1019
Sequence:
MRNGLVWLLHPALPGTLRSILGARPPPAKRLCGFPKQTYSTMSNPAIQRIEDQIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLLDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLRQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGYYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILSLEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKRYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL
  
Inhibitor
Name:
BDBM50459187
Synonyms:
CHEMBL4211765
Type:
Small organic molecule
Emp. Form.:
C90H128N24O24S
Mol. Mass.:
1962.191
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CNC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCC(O)=O)C(=O)NCC(=O)NCC(=O)NCC(=O)N2CCC[C@@H]2C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(O)=O)C(=O)N1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(N)=O |r|
Structure:
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