Reaction Details Report a problem with these data
Target
Son of sevenless homolog 1
Ligand
BDBM50459433
Substrate
n/a
Meas. Tech.
ChEMBL_1766509 (CHEMBL4201756)
EC50
13400±n/a nM
Citation
 Hodges, TR; Abbott, JR; Little, AJ; Sarkar, D; Salovich, JM; Howes, JE; Akan, DT; Sai, J; Arnold, AL; Browning, C; Burns, MC; Sobolik, T; Sun, Q; Beesetty, Y; Coker, JA; Scharn, D; Stadtmueller, H; Rossanese, OW; Phan, J; Waterson, AG; McConnell, DB; Fesik, SW Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem 61:8875-8894 (2018) [PubMed]  Article 
Target
Name:
Son of sevenless homolog 1
Synonyms:
SOS-1 | SOS1 | SOS1_HUMAN
Type:
PROTEIN
Mol. Mass.:
152470.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_839705
Residue:
1333
Sequence:
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISLTKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMHRDGPPLLENAHSS
  
Inhibitor
Name:
BDBM50459433
Synonyms:
CHEMBL4208983
Type:
Small organic molecule
Emp. Form.:
C26H27ClFN7
Mol. Mass.:
491.991
SMILES:
Cc1cc(Cn2c(nc3c(cc(Cl)cc23)-c2cnc(N)nc2C)N2CC3(CNC3)C2)cc(C)c1F
Structure:
Search PDB for entries with ligand similarity: