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Target
Kallikrein-13
Ligand
BDBM50459539
Substrate
n/a
Meas. Tech.
ChEMBL_1766599 (CHEMBL4201846)
IC50
>500±n/a nM
Citation
 De Vita, E; Schüler, P; Lovell, S; Lohbeck, J; Kullmann, S; Rabinovich, E; Sananes, A; Heßling, B; Hamon, V; Papo, N; Hess, J; Tate, EW; Gunkel, N; Miller, AK Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity. J Med Chem 61:8859-8874 (2018) [PubMed]  Article 
Target
Name:
Kallikrein-13
Synonyms:
3.4.21.- | KLK-L4 | KLK13 | KLK13_HUMAN | KLKL4 | Kallikrein 13 | Kallikrein-13 | Kallikrein-like protein 4
Type:
PROTEIN
Mol. Mass.:
30580.71
Organism:
Homo sapiens
Description:
ChEMBL_10853
Residue:
277
Sequence:
MWPLALVIASLTLALSGGVSQESSKVLNTNGTSGFLPGGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVLTAAHCLKEGLKVYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQTLPLSHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQVYPGKITDNMLCAGTKEGGKDSCEGDSGGPLVCNRTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRETIRKYETQQQKWLKGPQ
  
Inhibitor
Name:
BDBM50459539
Synonyms:
CHEMBL4206734
Type:
Small organic molecule
Emp. Form.:
C25H26N6O3
Mol. Mass.:
458.5123
SMILES:
Cc1nn(c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2cc(ccc12)C(N)=N)-c1ccccc1
Structure:
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