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Target
Glycine receptor subunit beta
Ligand
BDBM50459965
Substrate
n/a
Meas. Tech.
ChEMBL_1767830 (CHEMBL4219942)
EC50
661±n/a nM
Citation
 Cioffi, CL Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain. J Med Chem 61:2652-2679 (2018) [PubMed]  Article 
Target
Name:
Glycine receptor subunit beta
Synonyms:
GLRB | GLRB_HUMAN | Glycine receptor 58 kDa subunit | Glycine receptor alpha-3/beta | Glycine receptor subunit beta
Type:
PROTEIN
Mol. Mass.:
56135.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117714
Residue:
497
Sequence:
MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL
  
Inhibitor
Name:
BDBM50459965
Synonyms:
CHEMBL4227048
Type:
Small organic molecule
Emp. Form.:
C24H17F4NO3S
Mol. Mass.:
475.455
SMILES:
OC(=O)c1ccc(C[C@H]2Sc3c(F)cccc3N(Cc3ccccc3C(F)(F)F)C2=O)cc1 |r|
Structure:
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