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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM47402
Substrate
n/a
Meas. Tech.
ChEMBL_1768164 (CHEMBL4220276)
Ki
11000±n/a nM
Citation
 Slusarczyk, M; Ferla, S; Brancale, A; McGuigan, C Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides. Bioorg Med Chem 26:551-565 (2018) [PubMed]  Article 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) | PYRF_METTH | pyrF
Type:
Enzyme
Mol. Mass.:
24909.45
Organism:
Methanobacterium thermoautotrophicum
Description:
n/a
Residue:
228
Sequence:
MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP
  
Inhibitor
Name:
BDBM47402
Synonyms:
2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-1,2,4-triazine-3,5-dione | 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione | 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-1,2,4-triazine-3,5-quinone | 2-[(2R,3R,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-1,2,4-triazine-3,5-dione | 6-AZAURIDINE | MLS000028524 | SMR000058273 | cid_5901
Type:
Small organic molecule
Emp. Form.:
C8H11N3O6
Mol. Mass.:
245.1894
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ncc(=O)[nH]c1=O
Structure:
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