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Target
Reverse transcriptase
Ligand
BDBM50154442
Substrate
n/a
Meas. Tech.
ChEMBL_1769204 (CHEMBL4221316)
IC50
4500±n/a nM
Citation
 Lacbay, CM; Menni, M; Bernatchez, JA; Götte, M; Tsantrizos, YS Pharmacophore requirements for HIV-1 reverse transcriptase inhibitors that selectively "Freeze" the pre-translocated complex during the polymerization catalytic cycle. Bioorg Med Chem 26:1713-1726 (2018) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50154442
Synonyms:
2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid | CHEMBL188448
Type:
Small organic molecule
Emp. Form.:
C11H7ClN2O4
Mol. Mass.:
266.637
SMILES:
OC(=O)c1nc([nH]c(=O)c1O)-c1ccc(Cl)cc1
Structure:
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