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Target
Integrase
Ligand
BDBM50076273
Substrate
n/a
Meas. Tech.
ChEMBL_1769236 (CHEMBL4221348)
IC50
34±n/a nM
Citation
 Faridoon, na; Mnkandhla, D; Isaacs, M; Hoppe, HC; Kaye, PT Synthesis and evaluation of substituted 4-arylimino-3-hydroxybutanoic acids as potential HIV-1 integrase inhibitors. Bioorg Med Chem Lett 28:1067-1070 (2018) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50076273
Synonyms:
(2R,3R)-2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acryloyloxy]-succinic acid | 1-chicoricacid | CHEMBL282731 | Cichoric acid (CHA) | HIV-1 Integrase Inhibitor | L-chicoric acid | cichoric acid
Type:
Small organic molecule
Emp. Form.:
C22H18O12
Mol. Mass.:
474.3711
SMILES:
OC(=O)[C@H](OC(=O)\C=C\c1ccc(O)c(O)c1)[C@@H](OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O |r|
Structure:
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