Reaction Details Report a problem with these data
Target
Probable L-lysine-epsilon aminotransferase
Ligand
BDBM50460476
Substrate
n/a
Meas. Tech.
ChEBML_1769547
IC50
1040±n/a nM
Citation
 Alluri, KK; Reshma, RS; Suraparaju, R; Gottapu, S; Sriram, D Synthesis and evaluation of 4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran] analogues against both active and dormant Mycobacterium tuberculosis. Bioorg Med Chem 26:1462-1469 (2018) [PubMed]  Article 
Target
Name:
Probable L-lysine-epsilon aminotransferase
Synonyms:
2.6.1.36 | L-lysine aminotransferase | LAT_MYCTU | Lysine 6-aminotransferase | Probable L-lysine-epsilon aminotransferase | lat
Type:
PROTEIN
Mol. Mass.:
49007.52
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_105536
Residue:
449
Sequence:
MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT
  
Inhibitor
Name:
BDBM50460476
Synonyms:
CHEMBL4225131
Type:
Small organic molecule
Emp. Form.:
C18H21NO4S2
Mol. Mass.:
379.494
SMILES:
COc1ccc(cc1)S(=O)(=O)N1CCC2(CC1)OCCc1ccsc21
Structure:
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