Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50313638
Substrate
n/a
Meas. Tech.
ChEMBL_1770303 (CHEMBL4222415)
EC50
823±n/a nM
Citation
 Dallagnol, JCC; Khajehali, E; van der Westhuizen, ET; Jörg, M; Valant, C; Gonçalves, AG; Capuano, B; Christopoulos, A; Scammells, PJ Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M J Med Chem 61:2875-2894 (2018) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50313638
Synonyms:
1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | CHEMBL608112
Type:
Small organic molecule
Emp. Form.:
C18H15NO4
Mol. Mass.:
309.316
SMILES:
COc1ccc(Cn2cc(C(O)=O)c(=O)c3ccccc23)cc1
Structure:
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