Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50460765
Substrate
n/a
Meas. Tech.
ChEMBL_1770304 (CHEMBL4222416)
EC50
4800±n/a nM
Citation
 Dallagnol, JCC; Khajehali, E; van der Westhuizen, ET; Jörg, M; Valant, C; Gonçalves, AG; Capuano, B; Christopoulos, A; Scammells, PJ Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M J Med Chem 61:2875-2894 (2018) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50460765
Synonyms:
CHEMBL4229203
Type:
Small organic molecule
Emp. Form.:
C25H25F2N5O2
Mol. Mass.:
465.4951
SMILES:
Cn1cc(cn1)-c1ccc(Cn2cc(C(=O)N[C@@H]3CCCC[C@H]3O)c3c(F)cc(F)cc23)cn1 |r|
Structure:
Search PDB for entries with ligand similarity: