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Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50460861
Substrate
n/a
Meas. Tech.
ChEMBL_1770487 (CHEMBL4222599)
EC50
>30000±n/a nM
Citation
 Ginnetti, AT; Paone, DV; Stauffer, SR; Potteiger, CM; Shaw, AW; Deng, J; Mulhearn, JJ; Nguyen, DN; Segerdell, C; Anquandah, J; Calamari, A; Cheng, G; Leitl, MD; Liang, A; Moore, E; Panigel, J; Urban, M; Wang, J; Fillgrove, K; Tang, C; Cook, S; Kane, S; Salvatore, CA; Graham, SL; Burgey, CS Identification of second-generation P2X3 antagonists for treatment of pain. Bioorg Med Chem Lett 28:1392-1396 (2018) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM50460861
Synonyms:
CHEMBL4229237
Type:
Small organic molecule
Emp. Form.:
C23H21ClF3N3O3
Mol. Mass.:
479.879
SMILES:
C[C@@H](NC(=O)c1cc(cc(c1)C(C)(C)O)-c1ccc(Cl)cn1)c1ccc([n+]([O-])c1)C(F)(F)F |r|
Structure:
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