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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50461458
Substrate
n/a
Meas. Tech.
ChEMBL_1771379 (CHEMBL4223491)
Ki
32±n/a nM
Citation
 Healy, MP; Allan, AC; Bailey, K; Billinton, A; Chessell, IP; Clayton, NM; Giblin, GMP; Kay, MA; Khaznadar, T; Michel, AD; Naylor, A; Price, H; Spalding, DJ; Stevens, DA; Swarbrick, ME; Wilson, AW Discovery of {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP Bioorg Med Chem Lett 28:1892-1896 (2018) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50461458
Synonyms:
CHEMBL4229200
Type:
Small organic molecule
Emp. Form.:
C23H20N2O6
Mol. Mass.:
420.4147
SMILES:
CCOc1c2C(=O)N(C(=O)c2c(OCC)c2ncccc12)c1ccc(CC(O)=O)cc1
Structure:
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