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Target
Complement factor D
Ligand
BDBM50462091
Substrate
n/a
Meas. Tech.
ChEMBL_1772733 (CHEMBL4229725)
IC50
100±n/a nM
Citation
 Iyer, A; Xu, W; Reid, RC; Fairlie, DP Chemical Approaches to Modulating Complement-Mediated Diseases. J Med Chem 61:3253-3276 (2018) [PubMed]  Article 
Target
Name:
Complement factor D
Synonyms:
3.4.21.46 | Adipsin | Adn | C3 convertase activator | CFAD_RAT | Cfd | Complement factor D | Df | Endogenous vascular elastase | Properdin factor D
Type:
PROTEIN
Mol. Mass.:
28445.72
Organism:
Rattus norvegicus
Description:
ChEMBL_117988
Residue:
263
Sequence:
MHSSVYLVALVVLEAAVCVAQPRGRILGGQEAMAHARPYMASVQVNGTHVCGGTLVDEQWVLSAAHCMDGVTKDEVVQVLLGAHSLSSPEPYKHLYDVQSVVLHPGSRPDSVEDDLMLFKLSHNASLGPHVRPLPLQREDREVKPGTLCDVAGWGVVTHAGRRPDVLQQLTVSIMDRNTCNLRTYHDGAITKNMMCAESNRRDTCRGDSGGPLVCGDAVEAVVTWGSRVCGNRRKPGVFTRVATYVPWIENVLSGNVSVNVTA
  
Inhibitor
Name:
BDBM50462091
Synonyms:
CHEMBL4241950
Type:
Small organic molecule
Emp. Form.:
C18H14O8
Mol. Mass.:
358.299
SMILES:
CC(=O)Oc1ccc(cc1C(O)=O)-c1ccc(OC(C)=O)c(c1)C(O)=O
Structure:
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