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Target
Complement component C9
Ligand
BDBM50462092
Substrate
n/a
Meas. Tech.
ChEMBL_1772714 (CHEMBL4229706)
IC50
500±n/a nM
Citation
 Iyer, A; Xu, W; Reid, RC; Fairlie, DP Chemical Approaches to Modulating Complement-Mediated Diseases. J Med Chem 61:3253-3276 (2018) [PubMed]  Article 
Target
Name:
Complement component C9
Synonyms:
C9 | CO9_HUMAN | Complement component C9 | Complement component C9a | Complement component C9b
Type:
PROTEIN
Mol. Mass.:
63164.16
Organism:
Homo sapiens
Description:
ChEMBL_117938
Residue:
559
Sequence:
MSACRSFAVAICILEISILTAQYTTSYDPELTESSGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFSVRKCHTCQNGGTVILMDGKCLCACPFKFEGIACEISKQKISEGLPALEFPNEK
  
Inhibitor
Name:
BDBM50462092
Synonyms:
CHEMBL4242254
Type:
Small organic molecule
Emp. Form.:
C30H20O12
Mol. Mass.:
572.4726
SMILES:
OC(=O)C1=C\C(=C/c2cc(cc(C(O)=O)c2O)C(c2ccc(O)c(c2)C(O)=O)c2ccc(O)c(c2)C(O)=O)C=CC1=O |c:41,t:3|
Structure:
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