Reaction Details Report a problem with these data
Target
Complement C2
Ligand
BDBM50462097
Substrate
n/a
Meas. Tech.
ChEMBL_1772711 (CHEMBL4229703)
IC50
500±n/a nM
Citation
 Iyer, A; Xu, W; Reid, RC; Fairlie, DP Chemical Approaches to Modulating Complement-Mediated Diseases. J Med Chem 61:3253-3276 (2018) [PubMed]  Article 
Target
Name:
Complement C2
Synonyms:
3.4.21.43 | C2 | C3/C5 convertase | CO2_HUMAN | Complement C2 | Complement C2a fragment | Complement C2b fragment
Type:
PROTEIN
Mol. Mass.:
83276.53
Organism:
Homo sapiens
Description:
ChEMBL_117946
Residue:
752
Sequence:
MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTEVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL
  
Inhibitor
Name:
BDBM50462097
Synonyms:
CHEMBL4247125
Type:
Small organic molecule
Emp. Form.:
C35H66N12O7
Mol. Mass.:
766.9747
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C=O |r|
Structure:
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