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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50462179
Substrate
n/a
Meas. Tech.
ChEMBL_1772845 (CHEMBL4229837)
Ki
0.400000±n/a nM
Citation
 Zajdel, P; Kos, T; Marciniec, K; Sata?a, G; Canale, V; Kami?ski, K; Ho?uj, M; Lenda, T; Koralewski, R; Bednarski, M; Nowi?ski, L; Wójcikowski, J; Daniel, WA; Nikiforuk, A; Nalepa, I; Chmielarz, P; Ku?mierczyk, J; Bojarski, AJ; Popik, P Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects. Eur J Med Chem 145:790-804 (2018) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50462179
Synonyms:
CHEMBL4245263
Type:
Small organic molecule
Emp. Form.:
C27H29FN4O3S
Mol. Mass.:
508.608
SMILES:
Fc1ccc2c(noc2c1)C1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cncc3ccccc23)CC1 |r|
Structure:
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