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Target
RNA-directed RNA polymerase
Ligand
BDBM50462413
Substrate
n/a
Meas. Tech.
ChEMBL_1775371 (CHEMBL4232363)
IC50
0.001000±n/a nM
Citation
 Grande, F; Occhiuzzi, MA; Ioele, G; Ragno, G; Garofalo, A Benzopyrroloxazines containing a bridgehead nitrogen atom as promising scaffolds for the achievement of biologically active agents. Eur J Med Chem 151:121-144 (2018) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50462413
Synonyms:
CHEMBL4248257
Type:
Small organic molecule
Emp. Form.:
C43H50FN9O7
Mol. Mass.:
823.9116
SMILES:
COC(=O)NC(C(C)C)C(=O)N1CCCC1c1ncc([nH]1)-c1ccc2-c3c(F)c4cc(ccc4n3COc2c1)-c1cnc([nH]1)C1CCCN1C(=O)C(NC(=O)OC)C(C)C
Structure:
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