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Target
Casein kinase II subunit alpha/beta
Ligand
BDBM11323
Substrate
n/a
Meas. Tech.
ChEMBL_1776110 (CHEMBL4233102)
Kd
790±n/a nM
Citation
 Di Micco, S; Pulvirenti, L; Bruno, I; Terracciano, S; Russo, A; Vaccaro, MC; Ruggiero, D; Muccilli, V; Cardullo, N; Tringali, C; Riccio, R; Bifulco, G Identification by Inverse Virtual Screening of magnolol-based scaffold as new tankyrase-2 inhibitors. Bioorg Med Chem 26:3953-3957 (2018) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha/beta
Synonyms:
Casein kinase 2 (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha alpha beta beta | Complex of catalytic (CK2α) and non-catalytic (CK2β) subunits
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 989485
Components:
This complex has 2 components.
Component 1
Name:
Casein kinase II subunit alpha
Synonyms:
CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a)
Type:
Enzyme
Mol. Mass.:
45151.12
Organism:
Homo sapiens (Human)
Description:
P68400
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
  
Component 2
Name:
Casein kinase II subunit beta
Synonyms:
CK II beta | CSK2B_RAT | Casein kinase II beta | Casein kinase II subunit beta | Ck2n | Csnk2b | Phosvitin
Type:
PROTEIN
Mol. Mass.:
24937.13
Organism:
Rattus norvegicus
Description:
EBI_10969
Residue:
215
Sequence:
MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
  
Inhibitor
Name:
BDBM11323
Synonyms:
4,5,6,7-tetrabromo-1H-1,2,3-benzotriazole | 4,5,6,7-tetrabromo-1H-benzotriazole (14) | CHEMBL177820 | TBB
Type:
Small organic molecule
Emp. Form.:
C6HBr4N3
Mol. Mass.:
434.708
SMILES:
Brc1c(Br)c(Br)c2[nH]nnc2c1Br
Structure:
Search PDB for entries with ligand similarity: