Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50462834
Substrate
n/a
Meas. Tech.
ChEMBL_1776531 (CHEMBL4233523)
Ki
126±n/a nM
Citation
 Khanfar, MA; Reiner, D; Hagenow, S; Stark, H Design, synthesis, and biological evaluation of novel oxadiazole- and thiazole-based histamine H Bioorg Med Chem 26:4034-4046 (2018) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50462834
Synonyms:
CHEMBL4250218
Type:
Small organic molecule
Emp. Form.:
C16H20ClN3O
Mol. Mass.:
305.802
SMILES:
Clc1ccc(Cc2noc(CCN3CCCCC3)n2)cc1
Structure:
Search PDB for entries with ligand similarity: