Reaction Details
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Muscarinic acetylcholine receptor M3
Ligand
BDBM50462906
Substrate
n/a
Meas. Tech.
ChEMBL_1776694 (CHEMBL4233686)
IC50
350±n/a nM
Citation
Thota, S; Rodrigues, DA; Pinheiro, PSM; Lima, LM; Fraga, CAM; Barreiro, EJ N-Acylhydrazones as drugs. Bioorg Med Chem Lett 28:2797-2806 (2018) [PubMed] Article More Info.:
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_RAT | Cholinergic, muscarinic M3 | Chrm-3 | Chrm3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66086.66
Organism:
RAT
Description:
Cholinergic, muscarinic M3 CHRM3 RAT::P08483
Residue:
589
Sequence:
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
Inhibitor
Name:
BDBM50462906
Synonyms:
CHEMBL3211778
Type:
Small organic molecule
Emp. Form.:
C13H10N2O3S
Mol. Mass.:
274.295
SMILES:
O=C(N\N=C\c1ccsc1)c1ccc2OCOc2c1
Structure:
