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Target
Histamine H3 receptor
Ligand
BDBM50462998
Substrate
n/a
Meas. Tech.
ChEMBL_1777018 (CHEMBL4234010)
Ki
148±n/a nM
Citation
 Espinosa-Bustos, C; Frank, A; Arancibia-Opazo, S; Salas, CO; Fierro, A; Stark, H New lead elements for histamine H Bioorg Med Chem Lett 28:2890-2893 (2018) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50462998
Synonyms:
CHEMBL4241911
Type:
Small organic molecule
Emp. Form.:
C27H30ClN5
Mol. Mass.:
460.014
SMILES:
Clc1nc(N2CCC(CC2)N2CCCCC2)c2ccn(Cc3cccc4ccccc34)c2n1
Structure:
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