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Target
2-Hydroxyacid oxidase 1
Ligand
BDBM60918
Substrate
n/a
Meas. Tech.
ChEMBL_1777442 (CHEMBL4234434)
IC50
7800±n/a nM
Citation
 Moya-Garzón, MD; Martín Higueras, C; Peñalver, P; Romera, M; Fernandes, MX; Franco-Montalbán, F; Gómez-Vidal, JA; Salido, E; Díaz-Gavilán, M Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1. J Med Chem 61:7144-7167 (2018) [PubMed]  Article 
Target
Name:
2-Hydroxyacid oxidase 1
Synonyms:
1.1.3.15 | GOX | Glycolate oxidase | Gox1 | HAOX1 | HAOX1_MOUSE | Hao-1 | Hao1 | Hydroxyacid oxidase 1
Type:
PROTEIN
Mol. Mass.:
41003.92
Organism:
Mus musculus
Description:
ChEMBL_118230
Residue:
370
Sequence:
MLPRLVCISDYEQHVRSVLQKSVYDYYRSGANDQETLADNIQAFSRWKLYPRMLRNVADIDLSTSVLGQRVSMPICVGATAMQCMAHVDGELATVRACQTMGTGMMLSSWATSSIEEVAEAGPEALRWMQLYIYKDREISRQIVKRAEKQGYKAIFVTVDTPYLGNRIDDVRNRFKLPPQLRMKNFETNDLAFSPKGNFGDNSGLAEYVAQAIDPSLSWDDITWLRRLTSLPIVVKGILRGDDAKEAVKHGVDGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIIWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
  
Inhibitor
Name:
BDBM60918
Synonyms:
5-Amino-2-hydroxy-benzoic acid | MESALAMINE | MLS001424012 | SMR000145728 | cid_4075
Type:
Small organic molecule
Emp. Form.:
C7H7NO3
Mol. Mass.:
153.1354
SMILES:
Nc1ccc(O)c(c1)C(O)=O
Structure:
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