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Target
Lysyl oxidase homolog 3
Ligand
BDBM50463615
Substrate
n/a
Meas. Tech.
ChEMBL_1778829 (CHEMBL4235821)
IC50
>100000±n/a nM
Citation
 Hajdú, I; Kardos, J; Major, B; Fabó, G; L?rincz, Z; Cseh, S; Dormán, G Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited. Bioorg Med Chem Lett 28:3113-3118 (2018) [PubMed]  Article 
Target
Name:
Lysyl oxidase homolog 3
Synonyms:
1.4.3.- | 1.4.3.13 | LOXL | LOXL3 | LOXL3_HUMAN | Lysyl oxidase homolog 3 | Lysyl oxidase-like protein 3 | Synonyms=LOXL
Type:
PROTEIN
Mol. Mass.:
83173.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117594
Residue:
753
Sequence:
MRPVSVWQWSPWGLLLCLLCSSCLGSPSPSTGPEKKAGSQGLRFRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHILCRELGFTEATGWTHSAKYGPGTGRIWLDNLSCSGTEQSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIEVEHHLQVEEVRIRPAVGWGRRPLPVTEGLVEVRLPDGWSQVCDKGWSAHNSHVVCGMLGFPSEKRVNAAFYRLLAQRQQHSFGLHGVACVGTEAHLSLCSLEFYRANDTARCPGGGPAVVSCVPGPVYAASSGQKKQQQSKPQGEARVRLKGGAHPGEGRVEVLKASTWGTVCDRKWDLHAASVVCRELGFGSAREALSGARMGQGMGAIHLSEVRCSGQELSLWKCPHKNITAEDCSHSQDAGVRCNLPYTGAETRIRLSGGRSQHEGRVEVQIGGPGPLRWGLICGDDWGTLEAMVACRQLGLGYANHGLQETWYWDSGNITEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGVICSETASDLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSARSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILTPNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEANRRFERYPGQTSNQII
  
Inhibitor
Name:
BDBM50463615
Synonyms:
CHEMBL4251179
Type:
Small organic molecule
Emp. Form.:
C20H21N5O5S
Mol. Mass.:
443.476
SMILES:
CCOC(=O)c1sc(N\N=C2\C(N)=NN(C2=O)c2ccccc2)c(C(=O)OCC)c1C |c:12|
Structure:
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