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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50463914
Substrate
n/a
Meas. Tech.
ChEMBL_1779693 (CHEMBL4236685)
IC50
1083±n/a nM
Citation
 Yang, R; Chen, Y; Pan, L; Yang, Y; Zheng, Q; Hu, Y; Wang, Y; Zhang, L; Sun, Y; Li, Z; Meng, X Design, synthesis and structure-activity relationship study of novel naphthoindolizine and indolizinoquinoline-5,12-dione derivatives as IDO1 inhibitors. Bioorg Med Chem 26:4886-4897 (2018) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50463914
Synonyms:
CHEMBL4241365
Type:
Small organic molecule
Emp. Form.:
C21H20N4O3S
Mol. Mass.:
408.473
SMILES:
CSc1ccn2c3c(c(C(=O)NCCN(C)C)c2c1)C(=O)c1cccnc1C3=O
Structure:
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