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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50463939
Substrate
n/a
Meas. Tech.
ChEMBL_1779694 (CHEMBL4236686)
Ki
1500±n/a nM
Citation
 Liu, R; Liu, L; Liu, T; Yang, X; Wan, Y; Fang, H Discovery and development of substituted tyrosine derivatives as Bcl-2/Mcl-1 inhibitors. Bioorg Med Chem 26:4907-4915 (2018) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50463939
Synonyms:
CHEMBL4244705
Type:
Small organic molecule
Emp. Form.:
C36H40N4O8S
Mol. Mass.:
688.79
SMILES:
CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)NS(=O)(=O)c1ccc(NCCCc2ccccc2)c(c1)[N+]([O-])=O |r|
Structure:
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