Reaction Details
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Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50465324
Substrate
n/a
Meas. Tech.
ChEMBL_1784570 (CHEMBL4256087)
IC50
0.350±n/a nM
Citation
Cui, Z; Wang, X; Koppermann, S; Thorson, JS; Ducho, C; Van Lanen, SG Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471. J Nat Prod 81:942-948 (2018) [PubMed] Article More Info.:
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
2.7.8.13 | MRAY_AQUAE | Phospho-N-acetylmuramoyl-pentapeptide-transferase | UDP-MurNAc-pentapeptide phosphotransferase | mraY
Type:
PROTEIN
Mol. Mass.:
40354.31
Organism:
Aquifex aeolicus (strain VF5)
Description:
ChEMBL_117805
Residue:
359
Sequence:
MLYQLALLLKDYWFAFNVLKYITFRSFTAVLIAFFLTLVLSPSFINRLRKIQRLFGGYVREYTPESHEVKKYTPTMGGIVILIVVTLSTLLLMRWDIKYTWVVLLSFLSFGTIGFWDDYVKLKNKKGISIKTKFLLQVLSASLISVLIYYWADIDTILYFPFFKELYVDLGVLYLPFAVFVIVGSANAVNLTDGLDGLAIGPAMTTATALGVVAYAVGHSKIAQYLNIPYVPYAGELTVFCFALVGAGLGFLWFNSFPAQMFMGDVGSLSIGASLATVALLTKSEFIFAVAAGVFVFETISVILQIIYFRWTGGKRLFKRAPFHHHLELNGLPEPKIVVRMWIISILLAIIAISMLKLR
Inhibitor
Name:
BDBM50465324
Synonyms:
CHEMBL4286766
Type:
Small organic molecule
Emp. Form.:
C38H63N11O17
Mol. Mass.:
945.9703
SMILES:
[H][C@](O[C@@H]1O[C@H](CN)[C@@H](O)[C@H]1OC)([C@H](NCCCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)N[C@@H](C(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1)[C@@H](O)C(C)C)C(O)=O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Structure:
